List of Spider-Man enemies - Wikipedia Most of the supervillains of Spider-Man would be introduced in The Amazing Spider-Man comic book starting with the Chameleon. The early villains would be introduced in the 1960s during the Silver Age of Comic Books, and created by Stan Lee and Steve Ditko. John Romita Sr. replaced Ditko starting with the Rhino. Gerry Conway later replaced Stan Lee and helped create new adversaries for the web ...